| Name of Institution: | University of Missouri |
|---|---|
| Institution Type: | Public University |
| Is there a medical school? | Yes |
| Is this a land-grant institution? | Yes |
| Vivarium Director: | Dr. Lon Dixon |
| Residency Program Director: | Dr. Craig Franklin |
| Who to Contact: | Dr. Craig Franklin |
| Address: | Research Animal Diagnostic Lab College of Veterinary Medicine 4011 Discovery Drive Columbia, MO 65201 |
| Phone: | 573-882-6623 |
| Fax: | 573-884-7521 |
| Email: | franklinc@missouri.edu |
| Vivarium Name: | Office of Animal Resources |
|---|---|
| AAALAC Accredited? | Yes |
| Describe management structure: | 2-5 Administratively distinct vivaria |
| Describe facility layout: | Animals housed in 5+ separate locations |
| Vivarium square footage: | 120,000 |
| Summary of Animal Populations and Clinical Activities: | The University of Missouri Comparative Medicine Program is based in the Office of Animal Resources (OAR) and the Research Animal Diagnostic Laboratory (RADIL). Furthermore, through the College of Veterinary Medicine, trainees have access to a wealth of expertise in a variety of veterinary disciplines (i.e. surgery, pathology, ophthalmology, internal medicine). The Office of Animal Resources (OAR) serves the needs of over 250 investigators with over 600 animal care and use protocols. Over 24,000 animals are housed in 12 animal facilities totaling almost 120,000 square feet of space and four local farms in Colleges and Schools of Medicine, Veterinary Medicine, Agriculture, and Biological Sciences and in the Dalton Cardiovascular Research Center and Life Science Center. Species of animals include rodents, rabbits, dogs, swine, African Clawed frogs, and "exotic" species. In addition to conventional and barrier animal housing space, there are specialized facilities for housing animals exposed to infectious microorganisms including BSL-2 and 3 agents, radioisotopes, or toxic chemicals. Surgery facilities for aseptic animal surgery and postoperative recovery also are available. The School of Medicine, College of Veterinary Medicine, Dalton Cardiovascular Research Center, and Division of Biological Sciences are AAALAC-accredited which attests to the high level of commitment MU has to the humane care and use of laboratory animals. At the OAR, trainees are active participants in surgeries, veterinary care, health monitoring programs, model development, investigator consultation, facility design and inspection, and protocol review for the MU Animal Care and Use Committee (ACUC). The 2008 daily animal census: Amphibians - 224 Cats - 72 Dogs - 44 Fish - 6400 Hamsters - 4 Mice - 31,179 Poultry - 37 Rabbits - 45 Rats - 1041 Swine (biomed) - 210 The Research Animal Diagnostic Laboratory (RADIL) is a preeminent laboratory animal diagnostic laboratory that receives over 350 necropsy accessions / week. Trainee activities in the RADIL include coordination of necropsy accessions, animal necropsy, interpretation of results from parasitology, microbiology, serology, clinical pathology and molecular biology laboratories, interpretation of histologic sections, preparation of reports and consultation with submitting veterinarians, scientists or facility managers. Trainees are exposed to a broad range of cases from many species including genetically engineered animals. Accession types include 1) health monitoring; 2) biopsies; 3) problem solving cases; 4) genetically engineered rodent phenotyping projects and 5) collaborative research projects that require histologic interpretation of tissues. The RADIL laboratories provide a window to the many contemporary problems and questions that face the laboratory animal community. This has led to development of a number of trainee research projects involving discovery and characterization of novel emerging pathogens, development of diagnostic tests and development of new animal models for human disease. Other training resources. In addition, the RADIL is home to NIH-funded Mutant Mouse (MMRRC; U42 RR14821) Rat (RRRC; P40 RR15210) and Swine Resource and Research Centers (NSRCC; U42 RR18877). These Centers serve as repositories for cryopreservation, production and characterization (phenotyping) of genetically engineered rodent strains and swine and insure the continued availability of scientifically valuable genetically engineered animals to the biomedical research community. Moreover, the centers are actively engaged in research and through them, tremendous laboratory animal medicine and pathology resources are available to trainees in the CMP. Trainees are exposed to care and management of diverse breeding colonies and the challenges of recurrent import and export of rodents. This environment also creates natural synergistic opportunities for interdisciplinary research. Collectively, these resources provide windows to the many contemporary questions that face the genetically engineered animal community. |
| Number of Veterinarians in program | 11 |
| Number of Veterinarians in program | 11 |
| Number of ACLAM Diplomates involved in the program | 9 |
| Number of Board Certified Pathologists: | 10 |
| Number of other veterinary specialists in the program: | 60 |
| Surgeries per week in the veterinary care unit: | 6 |
| Necropsies per week in the veterinary care unit: | 350 |
| Is this program recognized by ACLAM? | Yes |
|---|---|
| Does this program participate in the Uniform Application Process? | Yes |
| Number of concurrent Lab Animal Residents/trainees | 14 |
| What year did this residency program begin? | 1969 |
| How many residents/trainees have completed this program? | 91 |
| Of these, how many have subsequently become ACLAM Diplomates? | 65 |
| How many years (minimum) are required to complete this program (residency only)? | 3 |
| Is formal coursework offered? | Yes |
| Is a degree program associated with this residency? | Yes |
| What degree(s)? | MS or PhD |
| Which departments most commonly grant degree(s): | Pathobiology Area |
| Give an overview of this program, describing its particular strengths and any unique aspects that are not addressed in any of the other sections: | Please visit our web page (http://www.radil.missouri.edu/cmp/) for more information including the application procedure. The University Comparative Medicine training program provides two or more years of research training that can be combined with residency training. Our goal is to train comparative medical scientists who are capable of pursuing a number of career tracks. Most of our students perform a 1 year residency where they divide their time between two rotations: 1) clincal and administrative laboratory animal medicine at the office of animal resources (OAR) and 2) diagnostic and research patholgoy at the research animal diagnostic laboratory (RADIL). During year 1, students also perform a small research project. Following year one, students identify a research lab (via a variety of mechanisms but primarily through lab rotations) and begin the research phase of their training. During years 2 and 3, students write and submit an extramural grant proposal and their priority is in the research lab. Those concurrently pursuing a residency continue some “keep their feet wet” activities in the OAR or the RADIL. After 3 years, a certificate of residency (recognized by ACLAM) is awarded to those who have pursued the dual program. Students pursuing MS degrees complete their program and join the work force. Those pursuing PhD degrees go into the research lab 100% of the time and usually complete their programs in 5-6 years total. The program outlined is designed to train students interested in a combination of Laboratory Animal Medicine (often pursue ACLAM boards) and Research. MU also has a biodefense program that is essentially the same (may or may not be coupled with a residency), but focuses on biodefense research. Highlights of the MU program: Opportunity for combined residency and research programs Large research animal diagnostic laboratory (largest in academia) One of three mutant mouse regional resource centers The only mutant rat and swine resource centers in the country Large program (12-14 trainees with diverse interests) and alumni base (approx 90 graduates) Approximately 50 research labs to choose from Med school, vet school, animal science department and life sciences center on the same campus Columbia, MO if you like Midwest medium-sized college towns |
| Describe the research interests of the faculty: | The objective of research training is to provide a substantive foundation for competitive primary or collaborative research careers through 1) course work and seminars that give a broad exposure to biomedical sciences and comparative medicine, 2) an intense research experience to provide research competence in state-of-the-art experimental methodology, 3) instruction in fundamental concepts of funding procurement, development of grant-writing skills and laboratory and project management and 4) increasingly independent experience in every stage of the scientific research process. Trainees gain experience in experimental design, data collection, management, and analysis; searching and critical review of the literature (also provided by journal clubs and rounds) and manuscript preparation. MU is one of only a few campuses in the U.S. that has schools of medicine, veterinary medicine, and agriculture, along with strong programs in basic biological and physical sciences. . The combination of our research faculty, facilities, and related resources provides an exceptional training experience in animal-based biomedical research. Over 50 outstanding, well-funded research faculty from 17 different departments engaged in wide variety of biomedical research projects on this campus have enthusiastically agreed to serve as mentors for trainees in the CMP (see http://www.radil.missouri.edu/info/cmp/mentors.htm). All of our mentors have experience in all of the necessary components of successful training and mentorship. These mentors also participate in several very successful interdisciplinary programs including exercise and cardiovascular physiology, radiopharmaceuticals in cancer therapy, biomedical engineering, infectious disease, mutant animal biology and production, gender physiology and xenotransplantation. The diverse expertise of prospective research mentors allows trainees to match their research interests with those of an outstanding faculty mentor. Research training in the CMP occurs in three phases: 1) a small project performed during the residency year (does not apply to research only programs) 2) research rotations and 3) dissertation research. Training culminates with 1) a manuscript (for the MS degree) or preparation of a dissertation (for the PhD degree), 2) defense of the thesis/dissertation work to the trainee's graduate committee, and 3) submission of one or more manuscripts for publication. Research findings are also presented at regional and national scientific meetings. Formal coursework includes instruction in experimental design, biostatistics, granstmanship (which includes a mock study section review), laboratory and project management and career preparation. Trainees also prepare and submit an extramural grant applications, such as an NRSA Individual Postdoctoral Fellowship (F32) or K award, during their program. |
| Give a few literature citations of publications completed by trainees during their tenure in this program: | Manuscripts in which trainee is first author (2004-current) Cain C. Phillips TE. 2008. Developmental changes in conjunctiva-associated lymphoid tissue of the rabbit. Invest Ophthalmol Vis Sci 49(2):644-9. Not indexed in PubMed Central; PMID: 18235010 Drake, MT, LK Riley, and RS Livingston. 2008. Differential susceptibility of SD and CD rats to a novel Rat Theilovirus. Comp Med 58:458-64. PMCID: PMC2707126 Dyson, MC, M Alloosh, JP Vuchetich, EA Mokelke, and M Sturek. 2006. Components of metabolic syndrome and coronary artery disease in female Ossabaw swine fed excess atherogenic diet. Comp Med 56:35-45. Not indexed in PubMed Central; PMID:16521858 Ericsson, A, EK Steffen, and CE Wiedmeyer. Development and validation of a microbead fluorescent immunoassay for the measurement of murine microalbuminuria. J of Vet Clin Path. (Accepted with revisions.) Hsu, CC, B Carter, DA Williams, and CL Besch-Williford. 2004. Haematoloechus sp. Infection in Wild-Caught Northern Leopard Frogs (Rana pipiens). Cont Top Lab Anim Sci 43:14-16. Not indexed in PubMed Central; PMID:15636549 Hsu, CC, C Franklin, and LK Riley. 2007. Multiplex fluorescent immunoassay for the simultaneous detection of serum antibodies to multiple rodent pathogens. Lab Anim (NY) 36(8):36-8. Not indexed on NIH PubMed Central; PMID: 17721531 Hsu, CC, CE Wobus, EK Steffen, LK Riley, and RS Livingston. 2005. Development of a microsphere-based serologic multiplexed fluorescent immunoassay and a reverse transciptase PCR assay to detect murine norovirus 1 infection in mice. Clin Diagn Lab Immunol 12:1145-1151. PMCID: PMC1247840 Hsu, CC, DB Carter, DA Williams and CL Besch-Williford. 2004. Haematoloechus sp. infection in wild-caught northern leopard frogs (Rana pipiens). Cont Top Lab Anim Sci 43(6):14-16. Not indexed in PubMed Central; PMID: 15636549 Hsu, CC, LK Riley, and RS Livingston. 2007. Molecular characterization of three novel murine noroviruses. Virus Genes 34(2):147-155. PMCID: PMC2654006 Hsu, CC, LK Riley, HM Wills, and RS Livingston. 2006. Persistent infection and serologic cross-reactivity of three novel murine noroviruses. Comp Med 56:247-251. Not indexed in PubMed Central; PMID: 16941951 Johnson, CV, T Shelton, CJ Smith, L Ma, MC Perry, WA Volkert, and T Hoffman. 2006. Evaluation of combined 177Lu-DOTA-8-AOC-BBN (7-14) NH2GRP receptor-targeted radiotherapy and chemotherapy in PC-3 human prostate tumor cell xenografted SCID mice. Cancer Biother Radiopharm 21:155-166. PMCID: PMC2646369 Kashuba Benson, CM, JD Benson, and JK Critser. 2008. An improved cryopreservation method for a mouse embryonic stem cell line. Cryobiology 56(2):120-30. Not indexed on NIH PubMed Central; PMID: 18191827 Kashuba, CM, CC Hsu, AP Krogstad, and CL Franklin. 2005. Small mammal virology. Veterinary Clin North Am Exot Anim Pract 8:107-122. Not indexed in PubMed Central; PMID: 15585191 Kashuba-Benson, CM, JD Benson and JK Critser. 2007. An improved cryopreservation method for the R1 embryonic stem cell line. Cryobiology, 55(3):370. Krogstad, AP, JE Simpson, and SW Korte. 2005. Viral diseases of the rabbit. Veterinary Clin North Am Exot Anim Pract 8:123-138. Not indexed in PubMed Central; PMID 15585192 Manuel, CA, CC Hsu, LK Riley, and RS Livingston. 2008. Soiled bedding sentinel detection of murine norovirus 4 (MNV-4). J Am Assoc Lab Anim Sci 47(3):31-36. PMCID: PMC2654006 Myles, MH, RS Livingston, and CL Franklin. 2004. Pathogenicity of Helicobacter rodentium in A/JCr and SCID Mice. Comp Med 54:509-516. Not indexed in PubMed Central; PMID:15575369 Myles, MH, RS Livingston, BA Livingston, JM Criley, and CL Franklin. 2003. cDNA Array Analysis of Altered Gene Expression in Ceca of Helicobacter hepaticus Infected A/JCr Mice Before and After Development of Typhlitis. Infect Immun 71:3885-3893. PMCID: PMC162032 Myles, MH, BK Dieckgraefe, JM Criley, CL Franklin. 2007. Characterization of cecal gene expression in a differentially susceptible mouse model of bacterial-induced inflammatory bowel disease. Inflamm Bowel Dis 13(7):822-36. Not indexed in PubMed Central; PMID: 17455200 Patten Jr, C, MH Myles, CL Franklin, and RS Livingston. Cytokine Perturbations in C57BL/6 Mice following Pasteurella pneumotropica Inoculation. Comp Med. (accepted pending revisions) Simpson, JE, CW Schweinfest, GE Shull, LR Gawenis, NW Walker, KT Boyle, M Soleimani, and LL Clarke. 2007. PAT-1 (Slc26a6) is the predominant apical membrane Cl-/HCO3- exchanger in the upper villous epithelium of murine duodenum. Am J Physiol Gastrointest Liver Physiol 292(4):G1079-88. Not indexed on NIH PubMed Central; PMID: 17170027 Simpson, JE, LR Gawenis, NM Walker, KT Boyle, LL Clarke. 2006. Chloride conductance of CFTR facilitates basal Cl-/HCO3- exchange in the villous epithelium of intact murine duodenum. Am J Physiol Gastrointest Liver Physiol 288:G1241-51. Not indexed in PubMed Central; PMID 15650130 Simpson, JE, NM Walker, M Soleimani, and LL Clarke. Putative anion transporter-1 (Pat-1, Slc26a6) contributes to intracellular pH regulation during H+-dipeptide transport in the villous epithelium. Am J Physiol Gastrointest Liver Physiol. (In revision) Sittaramane V, A Sawant, MA Wolman, L Maves, MC Halloran and A Chandrasekhar A. 2009, The cell adhesion molecule Tag1, transmembrane protein Stbm/Vangl2, and Lamininalpha1 exhibit genetic interactions during migration of facial branchiomotor neurons in zebrafish.. Dev Biol, 325(2):363-73. Not indexed in PubMed Central; PMID: 19013446. Sittaramane V, and A Chandrasekhar. 2008. Expression of unconventional myosin genes during neuronal development in zebrafish. Gene Expr Patterns 8(3):161-70. Not indexed in PubMed Central; PMID: 18078791. Strittmatter, RR, and JC Schadt. 2007. Sex differences in the respiratory response to hemorrhage in the conscious, New Zealand white rabbit. Am J Physiol Regul Integr Comp Physiol 292(5):R1963-9. Not indexed in PubMed Central; PMID: 17272667 Winkelmann, CT, SD Figueroa, TL Rold, WA Volkert, and TJ Hoffman. 2006. Micro-imaging characterization of a B16-F10 melanoma metastasis mouse model. Mol Imaging 5:105-114. Not indexed in PubMed Central; PMID: 16954024 |
| Where will vacancies be advertised? | JAVMA, COMPMED, web page |
| When does this program begin? | any month |
| Description of the community: | MU is located in Columbia, Missouri, about halfway between Kansas City and St. Louis. National magazines, such as Money, frequently rate Columbia as one of the best places in the United States to live. See http://www.gocolumbiamo.com/ for information about Columbia. |
|---|---|
| Starting Annual Salary: | $37,368 |
| To what extent is travel to meetings, etc. paid for? | 1 meeting per year, beginning in year 2 |
| Is individual health insurance provided? | Yes |
| Is family health insurance provided? | No |
| Describe the residents responsibilities for night, weekend, and holiday coverage: | Residents are on call approximately one weekend per month with rotating holiday duties. |
| Number of annual vacation days granted: | 14 |
| Web Site: | http://www.radil.missouri.edu/info/cmp/ |
This information was last edited 2009-10-07
This page is maintained by Dr. Craig Franklin (franklinc@missouri.edu)