Give an overview of this program, describing its particular strengths and any unique aspects that are not addressed in any of the other sections | The UC San Diego Animal Care Program (ACP) facilities include over 25 sites, including many standard lab animal facilities as well as certain specialized areas (barrier facilities, ABSL-2 suites, aquatic animals – fish and amphibians), plus specialized service and educational support services and facilities (rodent phenotype core, gnotobiotic animal services, diagnostic services laboratory, imaging facilities and irradiation facilities). Among the unique facilities that are served is the School of Medicine’s Center for the Future of Surgery (CFS), the Birch Aquarium at Scripps Institution of Oceanography (BAS) and Scripps Institution of Oceanography (SIO) – both of the latter housing and using marine vertebrate and invertebrates species. The ACP operation also includes the Center for Automated Equipment Processing (CAEP) for research equipment sanitation and processing serving multiple research facilities, and a central Animal Operations Center (AOC) for in-vivo research program operational coordination and management. |
Describe any unique research interests of your faculty | Gnotobiotic research (primarily in mice), bioengineering, stem cell applications in medical treatment (e.g. – genetically modified autologous cells to correct heritable disease), developmental biology with unique species (e.g. – jerboas), marine biology and aquatic conservation biology, associations with work done at nearby zoological institutions (San Diego Zoo Global, Sea World) |
Give a few literature citations of publications completed by trainees during their tenure in this program | Fernandez C, Lubar AA, Vinetz JM, Matthias MA. Experimental Infection of Rattus norvegicus by the Group II Intermediate Pathogen, Leptospira licerasiae. Am J Trop Med Hyg. 2018 Aug;99(2):275-280. doi: 10.4269/ajtmh.17-0844. Epub 2018 Jun 21. PubMed PMID: 29943708; PubMed Central PMCID: PMC6090328. M Torres, J Frohlich. Successful Treatment Of Chronic Swim Bladder Distension in a leather bass (Dermatolepis dermatolepis) at the Birch Aquarium. Drum and Croaker. 2018; 49:18-25 Frohlich JR, Alarcón CN, Toarmino CR, Sunseri AK, Hockman TM. Comparison of Serial Blood Collection by Facial Vein and Retrobulbar Methods in C57BL/6 Mice. J Am Assoc Lab Anim Sci. 2018 Jul 1;57(4):382-391. doi:10.30802/AALAS-JAALAS-17-000134. Epub 2018 Jun 15. PubMed PMID: 29907166; PubMed Central PMCID: PMC6059217.
Yaksh TL, Hobo S, Peters C, Osborn KG, Richter PJ Jr, Rossi SS, Grafe MR, Eisenach JC. Preclinical toxicity screening of intrathecal oxytocin in rats and dogs. Anesthesiology. 2014 Apr;120(4):951-61. doi: 10.1097/ALN.0000000000000148. Erratum in: Anesthesiology. 2017 Jun;126(6):1209. PubMed PMID: 24492326; PubMed Central PMCID: PMC5392224.
Hockman TM, Cisternas AF, Jones B, Butt MT, Osborn KG, Steinauer JJ, Malkmus SA, Yaksh TL. Target engagement and histopathology of neuraxial resiniferatoxin in dog. Vet Anaesth Analg. 2018 Mar;45(2):212-226. doi: 10.1016/j.vaa.2017.10.005. Epub 2017 Dec 5. PubMed PMID: 29361418. |