Institution Type Public University
Is there a medical school? Yes
Is this a land-grant institution? Yes
Vivarium Director Dr. Karl Andrutis
Program Director Dr. Karl Andrutis
Who to Contact Elizabeth Nunamaker
Address PO Box 100006, 1600 Archer Rd, Gainesville, FL  32610
Phone (352) 273-9246
Fax (352) 273-9323
Email nunamaker@ufl.edu

Vivarium Information

Vivarium Name Animal Care Services
Is the facility AAALAC accredited? Yes
Describe management structure One central vivarium only
Describe the extent to which your facilities are centralized Animals housed in 5+ separate locations
Vivarium Square Feet 200,000
Summarize the nature of the animal population and the predominant types of clinical activities diverse range of species
mouse transgenic core and breeding colony
dog and cat breeding colonies
research programs in cancer, neuroscience, diabetes, immunology, gene therapy, infectious disease
ABSL2 and ABSL3 facilities
axenic and gnotobiotic research
Number of Veterinarians in program 7
Number of ACLAM Diplomates in program 7
Number of Boarded Pathologists 0
Number of Other Boarded Veterinary Specialists 0
Number of necropsies/week in the veterinary unit 25
Number of surgical cases/week in the veterinary unit 5

Training Program Details

Is this program recognized by ACLAM? Yes
Does this program participate in the Veterinary Internship & Residency Matching Program (VIRMP)? Yes
Number of concurrent residents 3
How many residents/trainees have completed this program? 7
Of these, how many have subsequently become ACLAM Diplomates? 4
In what year did the program accept its first trainee? 2007
How many years are required to complete this program (residency only)? 3
Is formal coursework offered? No
Is a degree program associated with this residency? No
If yes, what degree(s)?
Which departments most commonly grant degree(s)?
Give an overview of this program, describing its particular strengths and any unique aspects that are not addressed in any of the other sections The University of Florida Laboratory Animal Medicine Residency is an ACLAM-approved, 3-year, non-degree program supported by 8 ACLAM-boarded veterinarians with one double-boarded by the American College of Veterinary Pathology. As an AAALAC-accredited research program, Animal Care Services employs over 100 staff with more than 200,000gsf of animal facility space encompassing 20 buildings and housing approximately 15 species, providing residents with a broad range of diverse experiences. In addition to basic and bench science, Animal Care Services supports the research activities of 16 different colleges including the following professional schools: the College of Veterinary Medicine, the College of Medicine, the College of Dentistry, and the College of Pharmacy, as well as the UF Health Hospital and the Malcolm Randall VA Medical Center. The training program is designed to support three residents, one for each year of training.

The objectives of this program are to prepare residents to perform the following tasks:
• Prevent, control, diagnose, and treat diseases of laboratory animals
• Provide veterinary services to support research activities
• Consult with investigators on protocol development and selection of animal models
• Train animal care and research staff
• Conduct collaborative research
• Manage laboratory animal resource facilities
• Review and assess protocols for animal welfare
• Function as an Attending Veterinarian to support the IACUC
• Understand and interpret the laws, regulations, and guidelines for the humane care and use of animals in research
• Identify and complete an hypothesis-driven research project
• Submit research project results for publication in a peer-reviewed scientific journal
• Become prepared and eligible for the ACLAM board exam

Research Project
Research projects for formal publication need to be initiated during the first year of the program with the identification of a responsible faculty member and an appropriate research topic. A research plan must be developed, presented to the ACS faculty, and submitted to the IACUC for approval prior to commencement of the project. It is the intent of this research experience to train the residents in experimental problem solving, focusing on development of a scientific hypothesis, designing and planning experiments, data collection, record keeping, data analysis and interpretation as well as communication and publishing results. Each resident is expected to complete a research project, defend it in a research seminar before the faculty, and publish the results in a peer-reviewed scientific journal. Residents are encouraged to submit an application for funding to the ACLAM Foundation or to the AALAS GLAS program if the project meets the criteria for the respective grants.

Mandatory Attendance for All Residents
• Weekly Clinical Veterinary Rounds
• Weekly Seminars
• Weekly Journal Club
• Weekly Veterinary Staff Meetings
• Twice-a-month IACUC Meetings
• Weekend/Holiday Emergency On-Call : approximately monthly
• Annual Mock ACLAM Exam
• Monthly meetings with the Program Director

Residency Description
Upon beginning the program, residents participate in a month long orientation program during which they shadow licensed veterinary technicians and veterinarians to become familiar with building locations and species specifics. Residents are then assigned to a series of rotations under the guidance of a faculty veterinarian.

Residents perform daily rounds of the animal facilities under the guidance and supervision of the clinical veterinarians. This training provides sufficient time with rodents, large animals, and non-human primates (off-site at collaborative institution) to allow residents to become proficient with all laboratory animal species housed in ACS facilities. Under the guidance of the clinical veterinarians, the resident is responsible for individual cases with the objectives to learn to prevent, control, diagnose and treat diseases of laboratory animals and deliver veterinary services to support research activities. Additionally, the resident consults with investigators on protocol development and selection of animal models.

Residents also receive training in anatomic and clinical pathology. Residents gain experience in the interpretation of clinical and pathologic data and the recognition of lesions characteristic of the major diseases of laboratory animals. Residents participate in necropsy examinations and will learn to interpret the samples and cases under the guidance of a veterinarian. Residents are responsible for preparing a complete gross description of abnormal necropsy findings, formulation of morphologic diagnoses, and procurement of appropriate tissues for histopathology and pertinent ancillary examinations, plus trimming and submission of tissues for preparation of slides for microscopic examination. The gross and microscopic findings are then reviewed with the veterinarian. Residents participate in the sentinel testing program managed by the ACS Diagnostic Laboratory to learn the mechanics of the program and become proficient at blood and tissue sampling.

Residents are exposed to IACUC activities by attending IACUC meetings and inspections and by reviewing protocols with the veterinarians to learn the protocol and regulatory review process. Research experience is attained throughout the training experience but is especially focused during performance of the research project.

As residents progress to the second year, expectations are as described above but with increasing responsibility and independence. During the second and third years, residents may rotate through the following specialty areas: Germ Free, BSL2, the Mouse Models Core/Breeding Colony, surgery, and non-human primates. During the second year, a research plan must be developed and the research project must be in progress. Second and third year residents are also required to submit an abstract for the national AALAS meeting.

During their third year, residents are expected to spend significant time completing their research projects by finishing experiments, compiling and analyzing data from their research project, and preparing the manuscript for publication. Each resident must complete the research project, defend it in a research seminar before the faculty, and publish the results in a scientific journal. Third year residents may elect to do rotations through areas in which they have special interest or would like to gain additional experience.

Resident Perks
Residents receive the following benefits:
• 15 Annual Vacation Days
• 10 Annual Sick days
• Insurance with optional dental and vision plans
• Retirement and life insurance plans available
• Memberships: AALAS, FAALAS, AVMA, ASLAP
• Books and study materials
• Phone Allowance
Describe any unique research interests of your faculty analgesia
anesthesia
endpoint refinement
Give a few literature citations of publications completed by trainees during their tenure in this program UF LAM Resident Publications

Adeno- associated virus-mediated correction of a canine model of glycogen storage disease type Ia.
David A Weinstein • Catherine E Correia • Thomas Conlon • Andrew Specht • John Verstegen • Karine Onclin-Verstegen • Martha Campbell-Thompson • Gurmeet Dhaliwal • Layla Mirian • Holly Cossette • [...] • Nathalie Clement • Stacy Porvasnik • Laurie Fiske • Maggie Struck • Harvey E Ramirez • Juan Jordan • Karl Andrutis • Janice Y Chou • Barry J Byrne • Cathryn S Mah
Human gene therapy 02/2010; 21(7):903-10.

Response to Protocol Review Scenario: Room for improvement
Maggie B Struck • Karl A Andrutis
Lab Animal 05/2010; 39(5):134-5.

Effect of a short-term fast on ketamine-xylazine anesthesia in rats.
Maggie B Struck • Karl A Andrutis • Harvey E Ramirez • August H Battles
Journal of the American Association for Laboratory Animal Science: JAALAS 01/2011; 50(3):344-8.

Glycogen Storage Disease Type Ia in Canines: A Model for Human Metabolic and Genetic Liver Disease
Andrew Specht • Laurie Fiske • Kirsten Erger • Travis Cossette • John Verstegen • Martha Campbell-Thompson • Maggie B Struck • Young Mok Lee • Janice Y Chou • Barry J Byrne • Catherine E Correia • Cathryn S Mah • David A Weinstein • Thomas J Conlon
BioMed Research International 01/2011; 2011(1110-7243):646257.

Adeno-associated virus-mediated correction of a canine model of glycogen storage disease type Ia.
Weinstein DA, Correia CE, Conlon T, Specht A, Verstegen J, Onclin-Verstegen K, Campbell-Thompson M, Dhaliwal G, Mirian L, Cossette H, Falk DJ, Germain S, Clement N, Porvasnik S, Fiske L, Struck M, Ramirez HE, Jordan J, Andrutis K, Chou JY, Byrne BJ, Mah CS.
Hum Gene Ther. 2010 Jul;21(7):903-10.

Amendments for additional animals: not a minor amendment.
Jordán J, Andrutis K.
Lab Anim (NY). 2009 Aug;38(8):255-6.

Oncologic doses of zoledronic acid induce osteonecrosis of the jaw-like lesions in rice rats (Oryzomys palustris) with periodontitis.
Aguirre JI, Akhter MP, Kimmel DB, Pingel JE, Williams A, Jorgensen M, Kesavalu L, Wronski TJ.
J Bone Miner Res. 2012 Oct;27(10):2130-43.

Teriparatide [rhPTH (1-34)], but not strontium ranelate, demonstrated bone anabolic efficacy in mature, osteopenic, ovariectomized rats.
Ma YL, Zeng QQ, Porras LL, Harvey A, Moore TL, Shelbourn TL, Dalsky GP, Wronski TJ, Aguirre JI, Bryant HU, Sato M.
Endocrinology. 2011 May;152(5):1767-78.

Host genetic background impacts disease outcome during intrauterine infection with Ureaplasma parvum.
von Chamier M, Allam A, Brown MB, Reinhard MK, Reyes L.
PLoS One. 2012;7(8):e44047.

Immune profiling of BALB/C and C57BL/6 mice reveals a correlation between Ureaplasma parvum-Induced fetal inflammatory response syndrome-like pathology and increased placental expression of TLR2 and CD14.
Allam AB, von Chamier M, Brown MB, Reyes L.
Am J Reprod Immunol. 2014 Mar;71(3):241-51.

Dehydration parameters and standards for laboratory mice.
Bekkevold CM, Robertson KL, Reinhard MK, Battles AH, Rowland NE.
J Am Assoc Lab Anim Sci. 2013;52(3):233-9.

Breeding, Husbandry, Veterinary Care, and Hematology of Marsh Rice Rats (Oryzomys palustris), a Small Animal Model for Periodontitis.
Ignacio Aguirre, Kent Edmonds, Bernadette Zamora, Jennifer Pingel, Linda Thomas, Denisse Cancel, Laura Schneider, Mary Reinhard, August Battles, Mohammed Akhter, Donald Kimmel, Thomas Wronski.
JALAAS, 54 (1) January 2015, pp. 51-58.

Cutaneous Epitheliotropic T-cell Lymphoma in a Marsh Rice Rat (Oryzomys palustris)"
Bryan Taylor, Christine Bekkevold, Ignacio Aguirre, Karl Andrutis, Mary Reinhard.
Comparative Medicine, 65 (5), October 2015, pp. 416-419.

Evaluation of the Analgesic Activity of Tramadol and Buprenorphine after Voluntary Ingestion in Rats (Rattus norvegicus) Using Operant Measures
Bryan F. Taylor, Harvey E. Ramirez, August H. Battles, Karl Andrutis, John K. Neubert
JAALAS, 55 (1), January 2016. pp. 74-82
Where will vacancies be advertised? VIRMP
What month does the program begin? July

Living and Working

Starting Annual Salary $43,000
To what extent is travel to meetings, etc. paid for? National AALAS during 2nd and 3rd year; FAALAS; others case by case
Is individual health insurance provided? Yes
Is family health insurance provided? Yes
Describe any fees or tuition None
Describe the residents' responsibilities for night, weekend, and holiday coverage Emergency coverage one week per month.
How many annual vacation days are given? 15
How many annual sick days are given? 10
Briefly describe the community Gainesville is the county seat and largest city in Alachua County, Florida, and the principal city of the Gainesville, Florida Metropolitan Statistical Area (MSA). The population of Gainesville in the 2013 US Census was 127,488, a 2.4% growth from 2010. Gainesville is the largest city in the region of North Central Florida.

Gainesville is home to the University of Florida, the nation's eighth largest university campus by enrollment, as well as to Santa Fe College. The Gainesville MSA was ranked as the #1 place to live in North America in the 2007 edition of Cities Ranked and Rated. Also in 2007, Gainesville was ranked as one of the "best places to live and play" in the United States by National Geographic Adventure.
Institutional, facility, or training program web site  http://acs.ufl.edu/